Importance of HSP70 in Livestock - at cellular level

Abstract

SMRUTI RANJAN MISHRA, TAPAN KUMAR PALAI

Heat stress is a condition when the environmental temperature is higher than the upper critical temperature of the animal’s core body temperature. This results in an imbalance in body homeostasis of the animal. A large number of proteins are being constantly expressed in the animal’s body during the time of heat stress. Among all those proteins, heat shock proteins (HSPs) are the major family of proteins that have shown a great potential to ameliorate the deleterious effects of heat stress. HSP70 is a ubiquitously expressed protein, which protects cell from heat stress by maintaining cellular machinery through proper folding of denatured proteins and preventing cellular apoptosis. Therefore, it is paramount to know the mechanism of cellular protection by prevention of apoptosis during heat stress. The present review highlights the regulatory role of HSP70 on cellular machinery during heat stress.