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Ethno-medicinal studies of Brachystegia eurycoma Harms, Detarium microcarpum Guill. & Perr and Mucuna pruriens (L.) DC on Blood Glucose Levels, Liver Enzymes, and Lipid Profile of Female Wistar Rats

Godspower I. Onyeso, Kpobari W. Nkpaa, Uche P Wigwe.

Abstract
Aim: This study was designed to investigate the ethno-medicinal effect of Brachystegia eurycoma Harms (B. eurycoma), Detarium microcarpum Guill. & Perr (D. microcarpum) and Mucuna pruriens (L.) DC (M. pruriens) on blood glucose levels, liver enzymes, and lipid profile of female Wistar rats. Materials and Methods: B. eurycoma, D. microcarpum and M. pruriens aqueous seeds extract were administered at a single dose of 200 mgkg-1 body weight to the experimental animals individually and in combination daily for three weeks. Results: The blood glucose level in group II, IV and V (94.5±3.09, 99.5±3.77 and 100.0±5.83 mg dL-1) were significant different (p<0.05) when compared to group I (82.0±5.85 mg dL-1). HDL, LDL and TG concentration in groups III, IV and V were significant different (p>0.05) compare to the control. AST and ALT level in group II and III were also significant different (p<0.05) when compared to group I and V. However, group IV was significant higher (p<0.05) when compared to group II, III and V. Conclusions: This present study showed that administration of B. eurycoma, D. microcarpum and M. pruriens seeds extract at 200 mgkg-1 alone or in combination improved the level of blood glucose level, liver function profile and liver enzymes did not posed any significant health risk. In conclusion, B. eurycoma, D. microcarpum and M. pruriens may be safe for use as a soup thickener.

Key words: Brachystegia eurycoma Harms, Detarium microcarpum Guill. & Perr, Mucuna pruriens (L.) DC blood glucose, lipid profile, liver enzymes


 
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How to Cite this Article
Pubmed Style

Godspower I. Onyeso, Kpobari W. Nkpaa, Uche P Wigwe. Ethno-medicinal studies of Brachystegia eurycoma Harms, Detarium microcarpum Guill. & Perr and Mucuna pruriens (L.) DC on Blood Glucose Levels, Liver Enzymes, and Lipid Profile of Female Wistar Rats. J Mol Pathophysiol. 2016; 5(4): 66-72. doi:10.5455/jmp.20161024100412


Web Style

Godspower I. Onyeso, Kpobari W. Nkpaa, Uche P Wigwe. Ethno-medicinal studies of Brachystegia eurycoma Harms, Detarium microcarpum Guill. & Perr and Mucuna pruriens (L.) DC on Blood Glucose Levels, Liver Enzymes, and Lipid Profile of Female Wistar Rats. http://www.jmolpat.com/?mno=239437 [Access: June 20, 2019]. doi:10.5455/jmp.20161024100412


AMA (American Medical Association) Style

Godspower I. Onyeso, Kpobari W. Nkpaa, Uche P Wigwe. Ethno-medicinal studies of Brachystegia eurycoma Harms, Detarium microcarpum Guill. & Perr and Mucuna pruriens (L.) DC on Blood Glucose Levels, Liver Enzymes, and Lipid Profile of Female Wistar Rats. J Mol Pathophysiol. 2016; 5(4): 66-72. doi:10.5455/jmp.20161024100412



Vancouver/ICMJE Style

Godspower I. Onyeso, Kpobari W. Nkpaa, Uche P Wigwe. Ethno-medicinal studies of Brachystegia eurycoma Harms, Detarium microcarpum Guill. & Perr and Mucuna pruriens (L.) DC on Blood Glucose Levels, Liver Enzymes, and Lipid Profile of Female Wistar Rats. J Mol Pathophysiol. (2016), [cited June 20, 2019]; 5(4): 66-72. doi:10.5455/jmp.20161024100412



Harvard Style

Godspower I. Onyeso, Kpobari W. Nkpaa, Uche P Wigwe (2016) Ethno-medicinal studies of Brachystegia eurycoma Harms, Detarium microcarpum Guill. & Perr and Mucuna pruriens (L.) DC on Blood Glucose Levels, Liver Enzymes, and Lipid Profile of Female Wistar Rats. J Mol Pathophysiol, 5 (4), 66-72. doi:10.5455/jmp.20161024100412



Turabian Style

Godspower I. Onyeso, Kpobari W. Nkpaa, Uche P Wigwe. 2016. Ethno-medicinal studies of Brachystegia eurycoma Harms, Detarium microcarpum Guill. & Perr and Mucuna pruriens (L.) DC on Blood Glucose Levels, Liver Enzymes, and Lipid Profile of Female Wistar Rats. Journal of Molecular Pathophysiology, 5 (4), 66-72. doi:10.5455/jmp.20161024100412



Chicago Style

Godspower I. Onyeso, Kpobari W. Nkpaa, Uche P Wigwe. "Ethno-medicinal studies of Brachystegia eurycoma Harms, Detarium microcarpum Guill. & Perr and Mucuna pruriens (L.) DC on Blood Glucose Levels, Liver Enzymes, and Lipid Profile of Female Wistar Rats." Journal of Molecular Pathophysiology 5 (2016), 66-72. doi:10.5455/jmp.20161024100412



MLA (The Modern Language Association) Style

Godspower I. Onyeso, Kpobari W. Nkpaa, Uche P Wigwe. "Ethno-medicinal studies of Brachystegia eurycoma Harms, Detarium microcarpum Guill. & Perr and Mucuna pruriens (L.) DC on Blood Glucose Levels, Liver Enzymes, and Lipid Profile of Female Wistar Rats." Journal of Molecular Pathophysiology 5.4 (2016), 66-72. Print. doi:10.5455/jmp.20161024100412



APA (American Psychological Association) Style

Godspower I. Onyeso, Kpobari W. Nkpaa, Uche P Wigwe (2016) Ethno-medicinal studies of Brachystegia eurycoma Harms, Detarium microcarpum Guill. & Perr and Mucuna pruriens (L.) DC on Blood Glucose Levels, Liver Enzymes, and Lipid Profile of Female Wistar Rats. Journal of Molecular Pathophysiology, 5 (4), 66-72. doi:10.5455/jmp.20161024100412





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